Chitosan-cartilage extracellular matrix hybrid scaffold induces chondrogenic differentiation to adipose-derived stem cells

I-Chan Lin,Tsung-Jen Wang,Chien-Liang Wu,Dai-Hua Lu,Yi-Ru Chen,Kai-Chiang Yang

Regenerative Therapy（2020）

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摘要

•Cultivation of ASCs in the chitosan and cartilage ECM hybrid scaffold induced chondrogenesis.•ASCs in composite scaffold expressed cartilage-specific genes COL2A1 and ACAN.•Histologic inspections showed abundant cartilage-specific collagen type II and proteoglycan productions.•Chitosan-cartilage ECM hybrid scaffold exhibits great potentials for ASC-based cartilage tissue engineering.

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关键词

Adipose-derived stem cell,Chitosan,Chondrogenesis,Extracellular matrix,Tissue-engineered cartilage

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