Liver hydrolysate prevents depressive-like behavior in an animal model of colitis: involvement of hippocampal neurogenesis via the AMPK/BDNF pathway.
Behavioural Brain Research(2020)
摘要
•DSS-treated mice show IBD-like pathology and signs of depression.•Liver hydrolysate reverses these inflammatory and behavioral changes.•It increases hippocampal neurogenesis through the AMPK/BDNF pathway.•It also attenuates anti-neuroinflammation in the hippocampus.•Liver hydrolysate may have therapeutic benefits in IBD and depression.
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关键词
AICAR,AMPK,ANOVA,BDNF,BrdU,CNS,DAI,DAPI,DCX,DG,DSS,GFAP,Iba1,IBD,IgG,i.p.,IL-6,LH,NeuN,PBS,PBSGT,p.o.,ROI,SEM,TNF-α
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