Protein functionality as a potential bottleneck for somatic revertant variants.

Fabian M P Kaiser,Ismail Reisli,Ingrid Pico-Knijnenburg,Anton W Langerak,François G Kavelaars,Hasibe Artac,Hanna IJspeert,Mirjam van der Burg

The Journal of allergy and clinical immunology（2020）

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摘要

Somatic revertants frequently occur in the slipstream of pathogenic germline mutations, but protein functionality may act as a bottleneck in the selection for functional variants.

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