CREBH knockout accelerates hepatic fibrosis in mouse models of diet-induced nonalcoholic fatty liver disease.

Guixin Li,Junli Zhang,Qianqian Jiang,Beibei Liu,Keshu Xu

Life Sciences（2020）

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摘要

•CREBH deficiency aggravates hepatic fibrosis in NAFLD mouse models.•CREBH deficiency enhances TGF-β signaling pathway.•CREBH deficiency inhibits expression of FGF21.•CREBH can be a potential therapeutic strategy of NAFLD.

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关键词

NAFLD,NASH,cAMP,CREBH,ERS,KO,WT,MCD,CD,HF,H&E,HSCs,αSMA,ALT,AST,TG,TCHO,HDL-C,LDL-C,qRT-PCR,GAPDH,MCP-1,BAX,COL-1,CCND1,TGF-β1,SMAD2/3,SD,TNFα,TIMP-1,MMP-9,CTGF,ECM,TGF-β2,FGF21,IR

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