Costunolide improved dextran sulfate sodium-induced acute ulcerative colitis in mice through NF-κB, STAT1/3, and Akt signaling pathways.

Fan Xie,Hai Zhang,Chuan Zheng,Xiao-Fei Shen

International Immunopharmacology（2020）

引用 36|浏览8

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摘要

•Costunolide improves DSS-induced acute colitis symptoms in mice.•Costunolide reduces the levels of pro-inflammatory cytokines in DSS-exposed colons.•Costunolide inhibits DSS-induced activation of NF-κB, STAT1/3, and Akt in colons.

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关键词

Costunolide,Inflammatory bowel disease,Acute ulcerative colitis,NF-κB,STAT1/3,Akt

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