Comparison of Sheep, Goats, and Calves as Infection Models for Mycobacterium avium subsp. paratuberculosis.

•Earliest responses to infection were observed at 90 days in sheep and goats.•Calves had more robust and sustained responses during the 12-month infection period.•Goats had higher expression of IL-4, IL-12, and IL-17 in antigen-stimulated PBMCs.•Overall, calves had the greatest level of MAP tissue infectivity and goats had the lowest level.