miR-429-CRKL axis regulates clear cell renal cell carcinoma malignant progression through SOS1/MEK/ERK/MMP2/MMP9 pathway.

Jinxia Wang,Chengyi Wang,Qian Li,Chunmei Guo,Weibin Sun,Dongting Zhao,Sixiong Jiang,Lihong Hao,Yuxiang Tian,Shuqing Liu,Ming-Zhong Sun

Biomedicine & Pharmacotherapy（2020）

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摘要

•miR-429 deficiency reversely correlates with CRKL upregulation in ccRCC.•miR-429 suppresses the in vitro migration and invasion capacities of ccRCC cells.•CRKL is a direct functional effector of miR-429 in ccRCC cell invasiveness.•miR-429 reverses TGF-β-induced CRKL expression and malignancy of ccRCC cells.•miR-429-CRKL axis regulates ccRCC via SOS1/MEK/ERK/MMP2/MMP9 pathway.

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关键词

Clear cell renal carcinoma(ccRCC),MiR-429-CRKL axis,Tumorigenesis,SOS1/MEK/ERK/MMP2/MMP9 pathway

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