Phthalocyanines for G-quadruplex aptamers binding.

Jéssica Lopes-Nunes,Josué Carvalho,Joana Figueiredo,Catarina I V Ramos,Leandro M O Lourenço,João P C Tomé,Maria G P M S Neves,Jean-Louis Mergny,João A Queiroz,Gilmar F Salgado,Carla Cruz

Bioorganic Chemistry（2020）

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摘要

•Zn(II)-phthalocyanine derivatives are proposed as ligands of G-quadruplex aptamers.•AS1411 and its derived sequences AT11, -L0 and -B0 are used to deliver the ligands.•Docking simulations suggest an end-stacking mode of interaction for the ligands.•ZnPc 4 presented the highest affinity and conformational changes on the G4 structures.•ZnPc 3 toxicity towards cancer cells was enhanced when complexed with G4 aptamers.

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关键词

G-quadruplex aptamers,Phthalocyanines,Biophysical characterization

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