Quantitative 1 H NMR analysis of a difficult drug substance and its exo-isomer as hydrochloride salts using alkaline deuterated methanol.

Journal of Pharmaceutical and Biomedical Analysis（2020）

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摘要

•Drug substances often times exist as salts.•Ionic compounds may be difficult to accurately quantitate by quantitative NMR.•Neutralization of salts and solubilization in situ can help resolve spectra.•Alkaline deuterated methanol can be used as a NMR solvent for ionic samples.

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关键词

Quantitative NMR,qNMR,Alkaline deuterated methanol,Hydrochloride salt,Purity,Analysis,Drug substance

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