A general approach for biomimetic mineralization of MOF particles using biomolecules.

•MOFs have great potential in biomolecule encapsulation and controlled release.•A general approach is developed for making biomolecule@MOFs.•The charge of biomolecules plays a critical role in forming MOF crystals.•Biomolecules with negatively charges induce the formation ZIF-8 particles.•Near neutral/positively charged biomolecules induce the formation of dia-Zn(HmIm)2.