A bioinspired mucoadhesive restores lubrication of degraded cartilage through reestablishment of lamina splendens.

Hongping Wan,Ke Ren,Hans J Kaper,Prashant K Sharma

Colloids and Surfaces B: Biointerfaces（2020）

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摘要

•Chitosan-catechol (Chi-C) recruits glycoproteins from the synovial fluid.•Glycoproteins reestablish the lamina splendens on the cartilage surface.•Reestablished lamina splendens restores the lubrication on degraded cartilage.•Chi-C is tissue friendly in nature.

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关键词

Cartilage lubrication,Chitosan,Catechol,Lamina splendens,Biolubrication

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