rLj-RGD4, the Shortened Peptide of rLj-RGD3 from Lampetra japonica, Protects Against Cerebral Ischemia/Reperfusion Injury via the PI3K/Akt Pathway.

Qilan Jia,Xin Zhang, Ailin Zhang,Rui Wu,Zhien Liu, Yiheng Chen,Jihong Wang,Li Lv

Peptides（2020）

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摘要

•The shortened peptide rLj-RGD4 is distributed in the I/R brain.•rLj-RGD4 has a protective effect in MCAO model rats established by I/R injury.•rLj-RGD4 has higher titer than rLj-RGD3.•rLj-RGD4 protects against cerebaral ischemia reperfusion injury partly via the Integrin-PI3K/Akt pathway.

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关键词

rLj-RGD4,Antiapoptosis,Cerebral ischemia/reperfusion,Rats,PC12 cell

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