LGR4, Not LGR5, Enhances hPSC Hematopoiesis by Facilitating Mesoderm Induction via TGF-Beta Signaling Activation

    Yu Wang
    Yu Wang
    Hongtao Wang
    Hongtao Wang
    Jie Gao
    Jie Gao
    Mengge Wang
    Mengge Wang
    Meijuan Xia
    Meijuan Xia
    Yuqi Wen
    Yuqi Wen

    Cell reports, pp. 1076002020.

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    Keywords:
    LGRshematopoietic differentiationhuman pluripotent stem cellsmesoderm

    Abstract:

    Attempts to generate functional blood cells from human pluripotent stem cells (hPSCs) remain largely unsuccessful, mainly due to the lack of understanding of the regulatory network of human hematopoiesis. In this study, we identified leucine-rich-repeat-containing G-protein-coupled receptor 4 (LGR4) as an essential regulator of early hema...More

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