Mixture toxicity of chlorpyrifos-methyl, pirimiphos-methyl, and nonylphenol in Atlantic salmon ( Salmo salar ) hepatocytes.

Toxicology Reports（2020）

引用 12|浏览4

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摘要

•Shotgun lipidomics points to combined effects on 18:0 and 18:1 lipid species.•Combined effects seen on membrane phospholipids and TAG in salmon hepatocytes.•Inhibited stearoyl CoA desaturase (SCD) and increased Δ6 desaturase (D6D) activity.•Adjuvants may amend toxicity of active ingredient in pesticide formulations.

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关键词

Organophosphorus pesticides,Nonylphenol,Mixture toxicity,Shotgun lipidomics,Multivariate analysis,3D cell culture

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