Thyroid hormone induces cellular senescence in prostate cancer cells through induction of DEC1.

Roland Kotolloshi,Kimia Mirzakhani, Joana Ahlburg,Florian Kraft,Thanakorn Pungsrinont,Aria Baniahmad

The Journal of Steroid Biochemistry and Molecular Biology（2020）

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摘要

•Thyroid hormones induce cellular senescence in prostate cancer cells.•Thyroid hormone-induced cellular senescence is mediated by DEC1 and p15/CDKN2B.•DEC1 is a direct target gene of Thyroid hormone receptor.•Identification of a novel pathway for thyroid hormone as a tumor suppressor.

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关键词

AR,DEC1,p15INK4B,p16INK4A,p21CIP1,PCa,PSA,SA-β-Gal,T3,TH,TR,TSH,T4,T2,rT3

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