Design, synthesis, and evaluation of a novel benzamidine-based inhibitor of VEGF-C binding to Neuropilin-2.

Ahmed M Said,Matthew W Parker,Craig W Vander Kooi

Bioorganic Chemistry（2020）

引用 8|浏览10

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摘要

•Nrp2 is critically involved in tumor metastasis.•There is no known small molecule inhibitor specific for Nrp2.•Identified a benzamidine based small molecule inhibitor with Nrp2 selectivity.•SAR was utilized to optimize potency and selectivity for Nrp2.

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关键词

Receptor,Neuropilin,Nrp-2,VEGF,Lymphatic,Angiogenesis,Benzamidine

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