Mechanism of PM 2.5 -induced human bronchial epithelial cell toxicity in central China.

Shuyin Duan,Meihua Zhang,Yaqiong Sun,Zhenya Fang,Hefeng Wang,Shuxian Li,Yanze Peng,Juan Li,Junxia Li,Jiaqi Tian,Haoyu Yin,Sanqiao Yao,Lin Zhang

Journal of Hazardous Materials（2020）

引用 23|浏览11

暂无评分

摘要

•PM2.5 in central China was abundant in heavy metals and organic pollutants.•Bioinformatics analysis predicted a crucial role of oxidative phosphorylation.•ATP5F, NDUF, COX7A, and UQCR in charge of ATP syntheses were dysregulated.•Suppression of ATP synthesis induced necroptosis of BEAS-2B cells.•N-acetylcysteine alleviated necroptosis of BEAS-2B cells exposed to PM2.5.

查看译文

关键词

Fine particulate matter,Bronchial epithelial cell,Oxidative phosphorylation,Necroptosis,N-acetylcysteine

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要