Antimicrobial peptide selection from Lippia spp leaf transcriptomes.

Letícia Stephan Tavares,Vinícius Carius de Souza,Vinícius Schmitz Nunes,Osmar Nascimento Silva,Gustavo Torres de Souza,Lucas Farinazzo Marques, Priscilla V Z Capriles Goliatt,Lyderson Faccio Viccini,Octávio Luiz Franco,Marcelo de Oliveira Santos

Peptides（2020）

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摘要

•Selection and modeling of AMPs derived from Lippia transcriptome.•Peptides were active against both gram-positive and gram-negative bacterial strains.•Hemolysis was mitigated through rational design of the peptides.•Successful selection of AMPs was modeled from Lippia transcriptome.•Former peptides were active against Gram-positive and Gram-negative bacteria.•Rational design reduced hemolytic activity in blood cells.

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