Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance.

EBioMedicine（2020）

引用 34|浏览51

暂无评分

摘要

A severely compromised metabolism lead to ERK pathway induction, and primes some HCC cells to pro-survival phenotypes upon ERK pathway blockade. Our findings offer novel insights for understanding, predicting and overcoming drug resistance in liver cancer patients. FUND: DFG, BMBF and Sino-German Cooperation Project.

查看译文

关键词

Metabolic state,Kinase inhibitors,Glutamine,Serine,Proliferation,Aerobic glycolysis,HCC

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要