m6A methyltransferase METTL3 promotes the progression of prostate cancer via m6A-modified LEF1.

European review for medical and pharmacological sciences（2020）

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摘要

METTL3 is upregulated in PCa tissues. METTL3 influences the activity of the Wnt pathway through m6A methylation on LEF1 mRNA, thereafter, promoting the progression of PCa.

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关键词

m6A,METTL3,LEF1,Wnt/beta-catean,Prostate cancer (PCa)

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