Inhibitory Effects of PRG4 on Migration and Proliferation of Human Venous Cells.

Lei Wang,Shinsuke Kikuchi,Tannin A Schmidt, Max Hoofnagle,Thomas N Wight,Nobuyoshi Azuma,Gale L Tang,Michael Sobel, Gautum R Velamoor,Nahush A Mokadam,Richard D Kenagy

Journal of Surgical Research（2020）

引用 9|浏览23

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摘要

Although rhPRG4 can inhibit the migration of venous SMCs, endothelial cells, and adventitial cells, and the proliferation of endothelial cells, PRG4 was only increased around medial SMCs in veins after ex vivo culture. PRG4 was not observed around medial SMCs in failed human vein grafts and varicose veins, suggesting the possibility that a failure of PRG4 upregulation may promote these pathologies.

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关键词

PRG4,Lubricin,Vein graft,Graft failure,Varicose vein,Human

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