Duloxetine ameliorates the impairment of diffuse noxious inhibitory control in rat models of peripheral neuropathic pain and knee osteoarthritis pain.

Sosuke Yoneda,Erika Kasai, Midori Matsuo,Ryuta Tamano,Yusuke Sakurai,Toshiyuki Asaki,Masahide Fujita

Neuroscience Letters（2020）

引用 8|浏览5

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摘要

•Forepaw injection of capsaicin produces a DNIC response in the hindpaw of rats.•DNIC response is reduced in rat chronic pain models.•Duloxetine, but not pregabalin and celecoxib, ameliorates the impairment of DNIC.

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关键词

Diffuse noxious inhibitory control,Neuropathic pain,Osteoarthritis pain,Duloxetine,Pregabalin,Celecoxib

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