A rare carbapenem-resistant hypervirulent K1/ST1265 Klebsiella pneumoniae with an untypeable bla KPC -harbored conjugative plasmid.

Cuidan Li,Guannan Ma,Tingting Yang,Xiaoyu Wen,Chuan Qin,Liya Yue,Xinmiao Jia,Yicheng Shen,Dandan Lu,Lifeng Wang,Dingxia Shen,Fei Chen

Journal of Global Antimicrobial Resistance（2020）

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摘要

•A rare carbapenem-resistant hypervirulent K1/ST1265 Klebsiella pneumoniae was analyzed.•The strain carries a blaKPC-harboured conjugative plasmid and a pLVPK-like virulent plasmid.•CR-HvKP strain could be evolved from various types of HvKP strains.•R-M system on plasmids may protect the plasmids from cleavage.•Pernicious CR-HvKP strains pose serious threats to public health.

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关键词

Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKP),Antimicrobial resistance,Transposon,Mobile genetic elements (MGEs),Horizontal gene transfer (HGT)

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