Effect of High-Intensity Interval Training in De Novo Heart Transplant Recipients - 3-year Results from the HITTS Randomized Controlled Trial

The primary outcome is the long-term effect of HIT vs MICT on aerobic exercise capacity as assessed by VO. Secondary outcomes are: Isokinetic muscular strength in the lower limbs by a dynamometer, body composition (bio-impedance analysis), left ventricular function by echo, heart rate response during the cardiopulmonary exercise test, relevant circulation biomarkers (renal function, NT-proBNP and cardiac troponins), HRQoL, tolerability, safety and adverse events.