CRISPR/Cas9-Based Transcriptional Activation of Endogenous IL-10 Gene in the Donor Lung for Transplantation
JOURNAL OF HEART AND LUNG TRANSPLANTATION(2020)
摘要
Using CRISPR/Cas9-based transcriptional modulation we have achieved targeted activation of the endogenous IL-10 gene in rat donor lungs. This proof of concept study opens the door to targeted gene modification of donor organs to improve outcomes after LTx.
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