Human Thrombomodulin Transgene Expression Prevents Intracardiac Thrombus in Life Supporting Pig-to-Baboon Cardiac Xenotransplantation

C.E. Goerlich,D. Kaczorowski,A. Singh,M. Abdullah,B. Lewis,T. Zhang,I. Tatarov, F. Sentz,A. Hershfeld, P. Odonkor,B. Williams,E. Strauss,D. Ayares, B. Griffith,M. Mohiuddin

JOURNAL OF HEART AND LUNG TRANSPLANTATION（2020）

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摘要

hTBM prevents intracardiac thrombus in this model. While immunologic rejection has been circumvented with novel immunosuppression regimens and GTKO, it is likely that hTBM or other transgenes involved in regulation of coagulation may be needed for prevention of thrombotic complications.

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intracardiac thrombus,pig-to-baboon

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