Pulmonary Microbiome Changes in Lung Transplant Recipients with Gastroesophageal Reflux

At time of GERD diagnosis, lung transplant recipients are more likely to have a pulmonary microbiome lower in diversity and enriched in oropharyngeal taxa. These perturbations are consistent with microaspiration and may contribute to allograft inflammation. Future studies are warranted to assess how the pulmonary microbiome changes over time in the context of GERD and its correlation with rejection and long-term outcomes.