Sequential inflammation model for Achilles tendinopathy by elastin degradation with treadmill exercise
Journal of Orthopaedic Translation(2020)
摘要
This discover the role of elastin degradation in tendinopathy and the interaction of exercise in the histological changes. The established the pathological model mimicking the pathogenesis to the human disease by injecting the elastase using ultrasound guidance and then applying treadmill exercise. The loss of elastin and change of collagen composition in clinical tendinopathy samples were observed in the rats. In addition, the sequential inflammation cascades were observed in the histological outcomes with combination of elastase injection and treadmill exercise. Thus, this model may be used to test the clinical treatment of tendinopathy in different stages.
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关键词
Elastase,Exercise,High-frequency ultrasound,Inflammation,Tendinopathy
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