Successful Transplantation of Porcine Lungs Following 3 Days of Preservation Using a Modified Cold Static Method Paired with Intermittent Normothermic Ex Vivo Lung Perfusion (EVLP)

A. Ali,A. Nykanen, E. Brambate, A. Mariscal,M. Chen, B. Wannberg, C. Price,B. Gomes, A. Wang,R. Ribeiro, V. Michaelsen, Y. Zhang,T.K. Waddell,M. Liu, S. Keshavjee,M. Cypel

JOURNAL OF HEART AND LUNG TRANSPLANTATION(2020)

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摘要
We demonstrate for the first time the feasibility of 3-day lung preservation leading to excellent early post-transplant outcomes. Further experiments are being performed to confirm these positive findings and underlying mechanisms. The combination of a modified CSP method (10°C) and intermittent EVLP can open new opportunities to further prolong organ preservation and provide time for advanced lung treatments and repair.
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