Engineered Mesenchymal Stromal Cell Therapy during Human Lung Ex Vivo Lung Perfusion is Affected by Lung Acidosis

MSC therapy rapidly increased perfusate IL-10 levels during human lung EVLP but was negatively affected by acidosis present in damaged lungs. Future studies will determine MSC effects on lung function and immunomodulation. The results imply that cell-based therapies are affected by target tissue acidosis, and that restoring metabolic conditions may optimize the effect of biologic therapies in damaged lungs.