Il-6 Receptor Blockade But Not Il-2 Treatment Contributes To Long-Term Nhp Cardiac Allograft Survival In Transient Mixed Chimeras

K. Ahrens,W. Sommer,J. Morrissette,D. Becerra,P. M. Patel,T. Costa, A. Dehnadi, I. M. Hanekamp, J. S. Allan,G. Benichou,J. C. Madsen

JOURNAL OF HEART AND LUNG TRANSPLANTATION（2020）

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摘要

Adding IL-6 receptor blockade to a mixed chimerism protocol has achieved tolerance of an isolated heart allograft for the first time. This protocol or a version thereof has the potential to be trialed in humans. The surprising deleterious effects of low dose IL-2 may be related to its ability to activate alloreactive T cells despite augmenting Tregs.

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