Deconvolution Of Donor And Recipient Transcripts From Frozen Lung Transplant Biopsies

We have demonstrated that it is possible to deconvolute donor and recipient transcripts at the earliest stages of reperfusion by taking advantage of SNVs. The resultant pathway analysis corresponds with our current knowledge of reperfusion biology. Following validation, we aim to apply this to less well-defined phenomena such as CLAD and to generalize the technique to solid-organ transplantation.