Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA M.C. Liu , G.R. Oxnard , E.A. Klein , C. Swanton , M.V. Seiden , Minetta C. Liu , Geoffrey R. Oxnard , Eric A. Klein , David Smith , Donald Richards , Timothy J. Yeatman , Allen L. Cohn , Rosanna Lapham , Jessica Clement , Alexander S. Parker , Mohan K. Tummala , Kristi McIntyre , Mikkael A. Sekeres , Alan H. Bryce , Robert Siegel , Xuezhong Wang , David P. Cosgrove , Nadeem R. Abu-Rustum , Jonathan Trent , David D. Thiel , Carlos Becerra , Manish Agrawal , Lawrence E. Garbo , Jeffrey K. Giguere , Ross M. Michels , Ronald P. Harris , Stephen L. Richey , Timothy A. McCarthy , David M. Waterhouse , Fergus J. Couch , Sharon T. Wilks , Amy K. Krie , Rama Balaraman , Alvaro Restrepo , Michael W. Meshad , Kimberly Rieger-Christ , Travis Sullivan , Christine M. Lee , Daniel R. Greenwald , William Oh , Che-Kai Tsao , Neil Fleshner , Hagen F. Kennecke , Maged F. Khalil , David R. Spigel , Atisha P. Manhas , Brian K. Ulrich , Philip A. Kovoor , Christopher Stokoe , Jay G. Courtright , Habte A. Yimer , Timothy G. Larson , Charles Swanton , Michael V. Seiden , Steven R. Cummings , Farnaz Absalan , Gregory Alexander , Brian Allen , Hamed Amini , Alexander M. Aravanis , Siddhartha Bagaria , Leila Bazargan , John F. Beausang , Jennifer Berman , Craig Betts , Alexander Blocker , Joerg Bredno , Robert Calef , Gordon Cann , Jeremy Carter , Christopher Chang , Hemanshi Chawla , Xiaoji Chen , Tom C. Chien , Daniel Civello , Konstantin Davydov , Vasiliki Demas , Mohini Desai , Zhao Dong , Saniya Fayzullina , Alexander P. Fields , Darya Filippova , Peter Freese , Eric T. Fung , Sante Gnerre , Samuel Gross , Meredith Halks-Miller , Megan P. Hall , Anne-Renee Hartman , Chenlu Hou , Earl Hubbell , Nathan Hunkapiller , Karthik Jagadeesh , Arash Jamshidi , Roger Jiang , Byoungsok Jung , TaeHyung Kim , Richard D. Klausner , Kathryn N. Kurtzman , Mark Lee , Wendy Lin , Jafi Lipson , Hai Liu , Qinwen Liu , Margarita Lopatin , Tara Maddala , M. Cyrus Maher , Collin Melton , Andrea Mich , Shivani Nautiyal , Jonathan Newman , Joshua Newman , Virgil Nicula , Cosmos Nicolaou , Ongjen Nikolic , Wenying Pan , Shilpen Patel , Sarah A. Prins , Richard Rava , Neda Ronaghi , Onur Sakarya , Ravi Vijaya Satya , Jan Schellenberger , Eric Scott , Amy J. Sehnert , Rita Shaknovich , Avinash Shanmugam , K.C. Shashidhar , Ling Shen , Archana Shenoy , Seyedmehdi Shojaee , Pranav Singh , Kristan K. Steffen , Susan Tang , Jonathan M. Toung , Anton Valouev , Oliver Venn , Richard T. Williams , Tony Wu , Hui H. Xu , Christopher Yakym , Xiao Yang , Jessica Yecies , Alexander S. Yip , Jack Youngren , Jeanne Yue , Jingyang Zhang , Lily Zhang , Lori (Quan) Zhang , Nan Zhang , Christina Curtis , Donald A. Berry Annals of Oncology（2020）
摘要
•Targeted methylation analysis of cfDNA simultaneously detected and localized >50 cancer types, including high-mortality cancers that lack screening paradigms.•Cancers were detected across all stages (stage I–III sensitivity: 43.9%; stage I–IV sensitivity: 54.9%) at a specificity of >99% and a single false positive rate of <1%.•This targeted methylation approach localized the tissue of origin with >90% accuracy, which will be critical for directing follow-up care.•This supports the continued investigation of this test with the goal of population-scale early multi-cancer detection.
更多 查看译文
关键词
cell-free DNA, next-generation sequencing, methylation, cancer
AI 理解论文
溯源树
样例
