Targeted Angiogenesis Gene Expression Profiling of Patients with Chronic Thromboembolic Pulmonary Hypertension

J. Arthur Ataam,M. Amsallem,K. Contrepois, J. Guihaire, F. Haddad,P. Dorfmuller,E. Fadel,O. Mercier

The Journal of Heart and Lung Transplantation（2020）

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摘要

These results suggest a downregulation of angiogenesis in endothelial cells from patients with CTEPH as compared to controls. Downregulation of genes involved in angiogenesis and dysfunctional PECs in CTEPH thrombi may underlie thrombus persistence.

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