Single Cell RNA Sequencing of Human Pulmonary Endarterectomy Specimen Reveals Distinct Cell Populations and Gene Profiles

Y.D. Zhao, S. Wanggou, M. Ding, X.Y. Dong, G. Zhao, Y. Diao,Y. Yao,L. Wu,J. Granton,M. de Perrot

The Journal of Heart and Lung Transplantation（2020）

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摘要

Single cell RNA sequencing demonstrates a large population of inflammatory cells combined with endothelial cells and smooth muscle cell in the cast of PEA. Endothelin-1 expression by endothelial cells may contribute to the development of PH in patients with CTEPH.

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