Abstract 457: Clearance of Senescent Cells Reduces TGFb Signaling and Aortic Dilatation in a Mouse Model of Marfan Syndrome

Michael A Hagler,Runqing Huang,Tamara Tchkonia,Tamar Pirtskhalava, Christina Inman,Carolyn M Roos,Bin Zhang,James L Kirkland,Jordan D Miller

Arteriosclerosis, Thrombosis, and Vascular Biology（2019）

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摘要

Marfan Syndrome (MFS) is often associated with progressive aortic root dilation, ultimately leading to aortic aneurysm and dissection. While recent work showed increased transforming growth factor ...

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