Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression

    Qingxiang Lin
    Qingxiang Lin
    Yong Zhang
    Yong Zhang
    Meichun Hu
    Meichun Hu
    Weikai Guo
    Weikai Guo
    Li Lai
    Li Lai
    Zhenliang Sun
    Zhenliang Sun

    Advanced science (Weinheim, Baden-Wurttemberg, Germany), pp. 19034832020.

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    Keywords:
    Wnt/β‐catenin/Snail pathwaybreast cancercancer metabolismpyruvate carboxylasesmall molecule ZY‐444

    Abstract:

    Rapid metabolism differentiates cancer cells from normal cells and relies on anaplerotic pathways. However, the mechanisms of anaplerosis-associated enzymes are rarely understood. The lack of potent and selective antimetabolism drugs restrains further clinical investigations. A small molecule ZY-444 (( -((5-(4-(benzyloxy)phenyl)-2-thiophe...More

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