Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression
Advanced science (Weinheim, Baden-Wurttemberg, Germany), pp. 19034832020.
Wnt/β‐catenin/Snail pathwaybreast cancercancer metabolismpyruvate carboxylasesmall molecule ZY‐444
Rapid metabolism differentiates cancer cells from normal cells and relies on anaplerotic pathways. However, the mechanisms of anaplerosis-associated enzymes are rarely understood. The lack of potent and selective antimetabolism drugs restrains further clinical investigations. A small molecule ZY-444 (( -((5-(4-(benzyloxy)phenyl)-2-thiophe...More
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