Asymmetric synthesis of linezolid thiazolidine-2-thione derivatives via CS2 mediated decarboxylation cyclization

De-Yun Cui,Hong-Tao Kong,Yi Yang,Jianfeng Cai,Bo-Yuan Shen,Da-chao Yan, Xiu-Juan Zhang, Ying-Long Qu,Meng-Meng Bai,En Zhang

Tetrahedron Letters（2020）

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摘要

•A decarboxylation cyclization method was developed.•This reaction was mediated by carbon disulfide.•A highly stereoselective synthesis of linezolid thiazolidine-2-thione derivatives.•Selected compounds showed anticancer effects on human cancer cells.

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关键词

Asymmetric synthesis,Cyclization,Stereoselectivity,Chirality,Linezolid thiazolidine-2-thione

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