P125 Local Pulse Wave Velocity in the Arterial Tree: Site Matters!

Several so-called loop-based methods, have been proposed to estimate local pulse wave velocity (PWV). However, previous studies have demonstrated inaccuracies in local PWV-estimates due to presence of reflections, which led to the proposition of a frequency-domain correction method [1]. The aim of this study is to assess the accuracy of PWV-estimates from different loop methods throughout the human arterial tree. The output data of a validated one-dimensional (1D) model of the human systemic circulation [2] was used to simulate the physiological signals needed on the estimations of local PWV methods, and this for model settings representing a young and an aged individual (stiffness increased by factor 2). Local PWV by the PU-loop, ln(D)U-loop, ln(D)P-loop, QA-loop and the frequency-domain (PWV1-5) methods, were compared against the reference value obtained from the Bramwell-Hill equation. Figure 1 shows the deviation (