A biodegradable thermosensitive hydrogel vaccine for cancer immunotherapy

•This vaccine activates and mature DCs both in vitro and in vivo.•This vaccine releases immunomodulators and antigens in a sustained manner.•This vaccine prolongs overall survival time of tumor-bearing mice.•This vaccine maintains a higher level of tumor necrosis factor in the serum.•This hydrogel may serve as an easily manufactured vaccine delivery platform.