Inactivation of the striatum in aged rats rescues their ability to learn a hippocampus-sensitive spatial navigation task.

Robert S Gardner,Paul E Gold,Donna L Korol

Neurobiology of Learning and Memory（2020）

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摘要

•Striatum inactivation reverses age-related learning impairments on a hippocampus-sensitive task.•Competitive interactions between memory systems contribute to cognitive aging.•Shifts in the balance across memory systems may mitigate age-related impairments.

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关键词

Aging,Spatial learning,Memory modulation,Memory system competition,Hippocampus,Striatum,Lidocaine

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