In vitro assessment of cobalt oxide particle dissolution in simulated lung fluids for identification of new decorporating agents.

Anne Van Der Meeren,David Lemaire,Sylvie Coudert, Guillaume Drouet, Myriam Benameur, Célia Gouzerh, Cien Yoong Hee, Pauline Brunquet, Bastien Trochaud,Magali Floriani,Christelle Gateau,Colette Lebrun,Pascale Delangle,Catherine Berthomieu,Véronique Malard

Toxicology in Vitro（2020）

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摘要

Inhalation of 60Co3O4 particles may occur at the work place in nuclear industry. Their low solubility may result in chronic lung exposure to γ rays. Our strategy for an improved therapeutic approach is to enhance particle dissolution to facilitate cobalt excretion, as the dissolved fraction is rapidly eliminated, mainly in urine.

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关键词

Cobalt oxide particles,Bioaccessibility,Dissolution and chelating agents,Lung,In vitro

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