Animal models for analysis of hypersensitivity reactions to Shuanghuanglian injection.

Molecular Immunology(2020)

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摘要
•SHLI induces anaphylactoid reactions in mouse, rat and dog models.•SHLI could activate the complement system in dogs and rats.•SHLI could produce an increase in vascular permeability.•We demonstrate a means for establishing an evaluation system of anaphylactoid reactions.
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关键词
Shuanghuanglian injection,Animal models,Anaphylactoid reaction,SC5b-9,Vascular permeability
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