Fibroblast Growth Factor Receptors as Targets for Radiosensitization in Head and Neck Squamous Cell Carcinomas.

Michael M Fisher,Gopika SenthilKumar,Rong Hu,Steve Goldstein,Irene Ong, Margot Miller,Sean R Brennan,Saakshi Kaushik,Lindsey Abel,Kwangok P Nickel,Gopal Iyer,Paul M Harari,Randall J Kimple,Andrew M Baschnagel

International Journal of Radiation Oncology*Biology*Physics（2020）

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摘要

These findings suggest that AZD4547 can augment the response of radiation in FGFR-expressing HNSCC in vivo model systems. FGFR1 and FGFR2 may prove worthy targets for radiosensitization in HNSCC clinical investigations.

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关键词

FGFR,head and neck cancer,radiation,radiosensitization

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