Inhibition of tumor suppressor p73 by nerve growth factor receptor via chaperone-mediated autophagy
Journal of molecular cell biology, 2020.
The tumor suppressor p73 is a homolog of p53 and is capable of inducing cell cycle arrest and apoptosis. Here, we identify nerve growth factor receptor (NGFR, p75NTR, or CD271) as a novel negative p73 regulator. p73 activates NGFR transcription, which, in turn, promotes p73 degradation in a negative feedback loop. NGFR directly binds to p...More
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