Inhibition of tumor suppressor p73 by nerve growth factor receptor via chaperone-mediated autophagy

Daniel Nguyen
Daniel Nguyen
Kun Yang
Kun Yang
Lucia Chao
Lucia Chao
Yun Deng
Yun Deng
Xiang Zhou
Xiang Zhou

Journal of molecular cell biology, 2020.

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Keywords:
HSPA8Lamp2aNGFRchaperone-mediated autophagyp73

Abstract:

The tumor suppressor p73 is a homolog of p53 and is capable of inducing cell cycle arrest and apoptosis. Here, we identify nerve growth factor receptor (NGFR, p75NTR, or CD271) as a novel negative p73 regulator. p73 activates NGFR transcription, which, in turn, promotes p73 degradation in a negative feedback loop. NGFR directly binds to p...More

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