SOCS3 protects against neonatal necrotizing enterocolitis via suppressing NLRP3 and AIM2 inflammasome activation and p65 nuclear translocation.

Hua Zhang,Yi Wang,Sixiu Li,Xiaojing Tang, Ruobing Liang, Xuefeng Yang

Molecular Immunology（2020）

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摘要

•LPS inhibited SOCS3 expression via JAK2/STAT3 pathway.•SOCS3 protects against NEC via suppressing NLRP3 and AIM2 inflammasome activation and p65 nuclear translocation.•SOCS3 mediates the immune response via a TLR4 dependent manner.

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关键词

Necrotizing enterocolitis,Enterocytes,Suppressor of cytokine signaling 3,Immune response

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