Early recruited neutrophils promote asthmatic inflammation exacerbation by release of neutrophil elastase.

•Airway neutrophils are accumulated in asthma prior to eosinophils.•Macrophage-derived chemokines cause neutrophilia in the lungs.•Neutrophils mediate asthmatic airway inflammation exacerbation by releasing NE.•The specific inhibition of NE alleviates asthmatic airway inflammation.