Shikonin ameliorates D-galactose-induced oxidative stress and cognitive impairment in mice via the MAPK and nuclear factor-κB signaling pathway.

Junjie Zhong,Zhifu Wang,Qiang Xie,Tianwen Li,Kezhu Chen,Tongming Zhu,Qisheng Tang,Chao Shen,Jianhong Zhu

International Immunopharmacology（2020）

引用 33|浏览10

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摘要

•Shikonin ameliorates D-gal induced cognitive impairment.•Shikonin ameliorates D-gal induced oxidative stress, astrocyte activation and neuronal damage in brain of D-gal induced mice.•Shikonin inhibited MAPK and NF-κB signaling pathway in brain of D-gal induced mice.

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关键词

Shikonin,D-gal,Oxidative stress,Inflammation,MAPK/ NF-κB

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