Impact of cumulative cisplatin dose and adjuvant chemotherapy in locally-advanced nasopharyngeal carcinoma treated with definitive chemoradiotherapy.

Marc Oliva, Shao Hui Huang,Rachel Taylor,Jie Su,Wei Xu,Aaron R Hansen,Raymond Jang,Andrew Bayley,Ali Hosni,Meredith Giuliani,Jolie Ringash,Scott V Bratman,John Cho,Jonathan Irish,John Waldron,Ilan Weinreb,John Kim,Brian O'Sullivan,Lillian L Siu,Anna Spreafico

Oral Oncology（2020）

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摘要

•Adjuvant chemotherapy was associated with OS benefit only in stage IV disease•Total CDDP-D >300 mg/m2 significantly improved 5-year OS in the entire cohort•Total and adjuvant CDDP-D were associated with higher OS and RFS in stage IV disease•Higher total and adjuvant CDDP-D trended to improve LRC but had no effect on DC

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关键词

Nasopharyngeal carcinoma,Chemoradiotherapy,Adjuvant chemotherapy,Cisplatin dose,Outcome

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