Blood biomarkers in patients with bicuspid aortic valve disease

Lidia R Bons,Laurie W Geenen,Allard T van den Hoven,Willem A Dik,Annemien E van den Bosch,Anthonie L Duijnhouwer,Hans-Marc J Siebelink,Ricardo P J Budde,Eric Boersma,Marja W Wessels,Ingrid M B H van de Laar,Marco C DeRuiter,Marie-José Goumans,Bart L Loeys,Jolien W Roos-Hesselink

Journal of Cardiology（2020）

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摘要

•A substantial number of patients with bicuspid aortic valve (BAV) have elevated levels of NT-proBNP, hsTnT, and hs-CRP.•Higher NT-proBNP is associated with aortic valve stenosis and regurgitation in BAV patients.•Higher hsTnT is associated with aortic valve regurgitation in BAV patients.•BAV patients have lower transforming growth factor-beta 1 levels than healthy controls.•This is the first study evaluating associations between biomarkers and disease stage in BAV patients.

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关键词

Transforming growth factor-beta 1,C-reactive protein,Troponin T,N-terminal pro-B-type natriuretic peptide,Bicuspid aortic valve

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